Indomethacin microspheres were prepared by emulsion solvent evaporation technique using various coat ratios. The matrixes comprised of hydroxypropyl methyl cellulose (HPMC), ethyl cellulose (EC), Eudragit® RL100 (EuRL100), Eudragit® RS100 (EuRS100) and cellulose acetate (CA). The morphology, flow properties, drug polymer interaction, release mechanism were studied. Anti-inflammatory activity of the prepared microspheres was compared with the commercial product using carrageenan induced paw edema method in rats. Pharmacokinetic evaluation was also carried out by plasma drug concentration method in rabbit to calculate t1/2, Cmax, Tmax, AUC and AUMC and MRT. Results of pharmacokinetic and pharmacodynamic study showed batch V formulation was statistically significant when compared to that of other formulations and marketed drug.
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